Prolonged high-fat diet induces gradual and fat depot-specific DNA methylation changes in adult mice

Scientific reports | 03-03-2017 | Abstract High-fat diets (HFD) are thought to contribute to the development of metabolism-related diseases. The long-term impact of HFD may be mediated by epigenetic mechanisms, and indeed, HFD has been reported to induce DNA methylation changes in white adipose tissue (WAT) near metabolism related genes. However, previous studies [...]

By |2017-06-26T11:01:40+01:00June 26th, 2017|Papers|Comments Off on Prolonged high-fat diet induces gradual and fat depot-specific DNA methylation changes in adult mice

Growing more positive with age: The relationship between reproduction and survival in aging flies

Experimental Gerontology | April 2017 | Abstract Populations of laboratory animals that are selected for increased lifespan often show negative correlated responses in early fecundity. However, late fecundity and/or total lifetime fecundity can be higher in the populations selected for increased lifespan. This has been interpreted by some as being at odds with the [...]

By |2017-06-20T13:23:51+01:00June 20th, 2017|Papers|Comments Off on Growing more positive with age: The relationship between reproduction and survival in aging flies

Dietary acid load, trabecular bone integrity, and mineral density in an ageing population: the Rotterdam study

Osteoporosis International: with other metabolic bone diseases | 12-04-2017 | Abstract We studied the relation between a diet that is high in acid-forming nutrients (e.g. proteins) and low in base-forming nutrients (e.g. potassium) and bone structure. We showed a negative relation, which was more prominent if proteins were of animal rather than of [...]

By |2017-06-20T12:44:20+01:00June 20th, 2017|Papers|Comments Off on Dietary acid load, trabecular bone integrity, and mineral density in an ageing population: the Rotterdam study

Protein-enriched familiar foods and drinks improve protein intake of hospitalized older patients: A randomized controlled trial

Cilincal Nutrition  | 12-05-2017 | Abstract Background & aims: Adequate protein intake is important in preventing and treating undernutrition. Hospitalized older patients are recommended to consume 1.2e1.5 g of protein per kg body weight per day (g/kg/d) but most of them fail to do so. Therefore, we investigated whether a range of newly [...]

By |2017-06-20T09:05:58+01:00June 20th, 2017|Papers|Comments Off on Protein-enriched familiar foods and drinks improve protein intake of hospitalized older patients: A randomized controlled trial

The Dietary Approaches to Stop Hypertension Diet, Cognitive Function, and Cognitive Decline in American Older Women

JAMDA | 01-06-2017 |   Abstract Objectives: To examine the association between long-term adherence to the Dietary Approaches to Stop Hypertension (DASH) diet with cognitive function and decline in older American women. Design: Prospective cohort study. Setting: The Nurses’ Health Study, a cohort of registered nurses residing in 11 US states. Participants: A [...]

By |2017-06-20T08:52:20+01:00June 20th, 2017|Papers|Comments Off on The Dietary Approaches to Stop Hypertension Diet, Cognitive Function, and Cognitive Decline in American Older Women

Doseeresponse effects of supplementation with calcifediol on serum 25-hydroxyvitamin D status and its metabolites: A randomized controlled trial in older adults

Clinical Nutrition | 26-03-2017 | Abstract Background & aims: Oral supplementation with vitamin D is recommended for older adults to maintain a sufficient 25-hydroxyvitamin D (25(OH)D) status throughout the year. While supplementation with vitamin D2 or D3 is most common, alternative treatment regimens exist which require further investigation with respect to increasing 25(OH)D [...]

By |2017-06-20T10:04:33+01:00June 20th, 2017|Papers|Comments Off on Doseeresponse effects of supplementation with calcifediol on serum 25-hydroxyvitamin D status and its metabolites: A randomized controlled trial in older adults

Activation-Induced Autophagy Is Preserved in CD4+ T-Cells in Familial Longevity

The Journal of Gerontology  | 09-05-2017 | Abstract As with many other tissues and organs, the immune system is also affected by age. Immunosenescence is characterized by a decreased ability of immune cells to mount a productive response upon exposure to new antigens. Several studies have reported that members of families with exceptional [...]

By |2017-06-20T09:09:34+01:00June 19th, 2017|Papers|Comments Off on Activation-Induced Autophagy Is Preserved in CD4+ T-Cells in Familial Longevity

Cellular senescence drives age-dependent hepatic steatosis

Nature Communications - 13-06-2017 Abstract: The incidence of non-alcoholic fatty liver disease (NAFLD) increases with age. Cellular senescence refers to a state of irreversible cell-cycle arrest combined with the secretion of proinflammatory cytokines and mitochondrial dysfunction. Senescent cells contribute to age-related tissue degeneration. Here we show that the accumulation of senescent cells promotes hepatic [...]

By |2017-06-19T08:54:33+01:00June 19th, 2017|Papers|Comments Off on Cellular senescence drives age-dependent hepatic steatosis

2nd Molecular Biology of Ageing Meeting 2017

Groningen, The Netherlands October 8 - 11, 2017 The 2nd Molecular of Biology of Ageing Meeting welcomes the submission of abstracts for original contributions to the field in the following scientific topics: - Telomeres - DNA repair and genome instability - Autophagy - Immunity - Mitochondria and Apoptosis - Protein homeostasis - [...]

By |2017-06-12T14:50:57+01:00June 12th, 2017|Meetings|Comments Off on 2nd Molecular Biology of Ageing Meeting 2017