J Gerontol A Biol Sci Med Science | November 2016 | Abstract: Background: Sarcopenia, or the loss of muscle mass and strength, is known to increase the risk for falls and (hip) fractures in older people. The objective of this study was to assess the skeletal muscle fiber characteristics in elderly female hip [...]
European Historical Population Samples Network | 31-01-2017 | Abstract The limits to human lifespan are a widely discussed topic. Yet, later-life mortality and longevity are generally studied from a genetic perspective, while the social dimension has received less attention. This paper gives a systematic overview of trends in later-life mortality and longevity for [...]
Aging Cell | 23-09-2017| Summary Calorie restriction (CR) is a dietary regimen that supports healthy aging. In this study, we investigated the systemic and liver-specific responses caused by a diet switch to a medium-fat (MF) diet in 24-month-old lifelong, CR-exposed mice. This study aimed to increase the knowledge base on dietary alterations of [...]
E life Sciences| 30 april 2018 Abstract Ageing is associated with physical decline and the development of age-related diseases such as metabolic disorders and cancer. Few conditions are known that attenuate the adverse effects of ageing, including calorie restriction (CR) and reduced signalling through the mechanistic target of rapamycin complex 1 (mTORC1) pathway. Synthesis [...]
Horizon - The EU Research & Innovation Magazine 5 juli 2018 The regenerative abilities of the flatworm Macrostomum lignano serve as a model for how humans might regenerate tissues. Image credit - Flickr/ Lukas Schärer, licensed under CC BY-SA 2.0 Research into the remarkable regenerative powers of worms and the insights they can give [...]
Persbericht LUMC - 7 januari 2019 Een lang leven is erfelijk, maar dat geldt primair voor personen uit families waarvan meerdere leden behoren tot de top tien procent overlevers van hun generatie. In de genen van deze families ligt waarschijnlijk de sleutel tot een lang leven. Dat schrijven onderzoekers van het Leids Universitair Medisch [...]
Niels van den Berg published a paper "Increasing number of long-lived ancestors marks a decade of healthspan extension and healthier metabolomics profiles" in Nature Communications in July 2023 Globally, the lifespan of populations increases but the healthspan is lagging behind. Previous research showed that survival into extreme ages (longevity) clusters in families as illustrated [...]
Yara van Holsteing et al. published a systematic review "The association of blood biomarkers with treatment response and adverse health outcomes in older patients with solid tumors: A systematic review" in the Journal of Geriatric Oncology in September 2023 Blood biomarkers are potentially useful prognostic markers and may support treatment decisions, but it is [...]
