Dear DuSRA members, Please SAVE THE DATA of the Annual DuSRA Meeting!!!! This year we will meet in Wageningen on October 14 and 15. Yes, an overnight program this year! Registration, program and venue details are soon to follow. We hope to see you in October in Wageningen!
Annelien de Kat et al. published a paper “Late reproduction is associated with extended female survival but not with familial longevity” in Reproductive BioMedicine Online in April 2024! “They concluded that female reproductive health associates with a longer lifespan, though women from long-lived families do not show extended reproductive health. Other factors in somatic [...]
Sergio Andreu-Sánchez et al. published a paper "Unraveling interindividual variation of trimethylamine N‐oxide and its precursors at the population level" in iMeta in March 2024 Trimethylamine N-oxide (TMAO) is a circulating microbiome-derived metabolite implicated in the development of atherosclerosis and cardiovascular disease (CVD). They investigated whether plasma levels of TMAO, its precursors (betaine, carnitine, [...]
Marije Sluiskes et al. published a paper "Clarifying the biological and statistical assumptions of cross-sectional biological age predictors: an elaborate illustration using synthetic and real data" in BMC Medical Research Methodology in March 2024 Their main conclusion was that cross-sectional methods for predicting biological age commonly use the untestable identical-association assumption, which previous literature [...]
Georges Janssens et al. published a paper “A conserved complex lipid signature marks human muscle aging and responds to short-term exercise” in Nature Aging in February 2024 Studies in preclinical models suggest that complex lipids, such as phospholipids, play a role in the regulation of longevity. However, identification of universally conserved complex lipid changes [...]
Thanh Hoang et al. published a paper "Comprehensive evaluation of smoking exposures and their interactions on DNA methylation" in eBioMedicine in February 2024 Many smoking-related methylation sites were identified with Illumina’s EPIC array. Most signals revert to levels observed in never smokers within a year of cessation. Many in utero smoking CpGs persist into [...]
Niels van den Berg published a paper "Increasing number of long-lived ancestors marks a decade of healthspan extension and healthier metabolomics profiles" in Nature Communications in July 2023 Globally, the lifespan of populations increases but the healthspan is lagging behind. Previous research showed that survival into extreme ages (longevity) clusters in families as illustrated [...]
Yara van Holsteing et al. published a systematic review "The association of blood biomarkers with treatment response and adverse health outcomes in older patients with solid tumors: A systematic review" in the Journal of Geriatric Oncology in September 2023 Blood biomarkers are potentially useful prognostic markers and may support treatment decisions, but it is [...]
The Netherlands Consortium of Dementia Cohorts has performed a meta-analysis with 8 cohort studies to investigate the associations between depressive symptoms later in life and plasma markers for Alzheimer’s disease and neurodegeneration. The Leiden Longevity Study was one of the participating cohorts. The results are published in “The American Journal of Geriatric Psychiatry” The [...]
A shift towards a more plant-based diet is promoted as healthy as well as sustainable. Whether this also applies to older adults is however less clear: On one hand plant-based diets may lead to energy deficits among vulnerable older adults and therefore negatively impact well-being. On the other hand, plant-based diets have been found [...]
