Depressive symptoms and plasma markers of Alzheimer’s disease and neurodegeneration: a coordinated meta-analysis of 8 cohort studies

The Netherlands Consortium of Dementia Cohorts has performed a meta-analysis with 8 cohort studies to investigate the associations between depressive symptoms later in life and plasma markers for Alzheimer’s disease and neurodegeneration. The Leiden Longevity Study was one of the participating cohorts. The results are published in “The American Journal of Geriatric Psychiatry” The [...]

By |2024-03-18T17:10:44+01:00March 18th, 2024|Highlighted announcements, News, Papers|Comments Off on Depressive symptoms and plasma markers of Alzheimer’s disease and neurodegeneration: a coordinated meta-analysis of 8 cohort studies

Healthful plant-based diet associates with greater well-being in older adults

A shift towards a more plant-based diet is promoted as healthy as well as sustainable. Whether this also applies to older adults is however less clear: On one hand plant-based diets may lead to energy deficits among vulnerable older adults and therefore negatively impact well-being. On the other hand, plant-based diets have been found [...]

By |2024-02-19T11:44:21+01:00February 19th, 2024|Archief papers, Highlighted announcements, News, Papers, Uncategorized|Comments Off on Healthful plant-based diet associates with greater well-being in older adults

Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair-deficient mice

Aging Cell - February 2021 Dietary restriction (DR) and rapamycin extend healthspan and life span across multiple species. We have recently shown that DR in progeroid DNA repair-deficient mice dramatically extended healthspan and trippled life span. Here, we show that rapamycin, while significantly lowering mTOR signaling, failed to improve life span nor healthspan of [...]

By |2021-04-19T14:47:37+01:00March 2nd, 2021|News, Nieuws VOILA, Papers|Comments Off on Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair-deficient mice

Emerging Role of C/EBPβ and Epigenetic DNA Methylation in Ageing

Trends in genetics - Volume 36, Issue 2, February 2020 Christof Niehrs (Institute of Molecular Biology), Cornelis F. Calkhoven (European Research Institute for the Biology of Ageing) Ageing is closely associated with and influenced by energy metabolism, and C/EBPβ is emerging as a key regulator of energy metabolism and longevity. DNA hypermethylation in GADD45α/ING1 [...]

By |2020-01-15T09:25:06+01:00January 15th, 2020|News, Papers|Comments Off on Emerging Role of C/EBPβ and Epigenetic DNA Methylation in Ageing

A meta-analysis of genome-wide association studies identifies multiple longevity genes

Nature Communications - Augustus 2019 Human longevity is heritable, but genome-wide association (GWA) studies have had limited success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity phenotype definition including 11,262/3484 cases surviving at or beyond the age corresponding to the 90th/99th survival percentile, respectively, and 25,483 controls whose age at [...]

By |2020-01-15T09:29:26+01:00September 10th, 2019|News, Papers|Comments Off on A meta-analysis of genome-wide association studies identifies multiple longevity genes

DNA methylation as a mediator of the association between prenatal adversity and risk factors for metabolic disease in adulthood

Science Advances | 03-01-2018 Abstract Although it is assumed that epigenetic mechanisms, such as changes in DNA methylation (DNAm), underlie the relationship between adverse intrauterine conditions and adult metabolic health, evidence from human studies remains scarce. Therefore, we evaluated whether DNAm in whole blood mediated the association between prenatal famine exposure and metabolic health [...]

By |2018-02-05T11:12:37+01:00February 5th, 2018|News, Papers|Comments Off on DNA methylation as a mediator of the association between prenatal adversity and risk factors for metabolic disease in adulthood

A p300 and SIRT1 Regulated Acetylation Switch of C/EBPa Controls Mitochondrial Function

Cell Press  | 9 januari 2018 | Summary Cellular metabolism is a tightly controlled process in which the cell adapts fluxes through metabolic  pathways in response to changes in nutrient supply. Among the transcription factors that regulate  gene expression and thereby cause changes in cellular metabolism is the basic leucine-zipper (bZIP) transcription factor CCAAT/enhancer-binding [...]

By |2018-01-22T10:09:37+01:00January 22nd, 2018|News, Papers|Comments Off on A p300 and SIRT1 Regulated Acetylation Switch of C/EBPa Controls Mitochondrial Function

Prolonged high-fat diet induces gradual and fat depot-specific DNA methylation changes in adult mice

Scientific reports | 03-03-2017 | Abstract High-fat diets (HFD) are thought to contribute to the development of metabolism-related diseases. The long-term impact of HFD may be mediated by epigenetic mechanisms, and indeed, HFD has been reported to induce DNA methylation changes in white adipose tissue (WAT) near metabolism related genes. However, previous studies [...]

By |2017-06-26T11:01:40+01:00June 26th, 2017|Papers|Comments Off on Prolonged high-fat diet induces gradual and fat depot-specific DNA methylation changes in adult mice

Growing more positive with age: The relationship between reproduction and survival in aging flies

Experimental Gerontology | April 2017 | Abstract Populations of laboratory animals that are selected for increased lifespan often show negative correlated responses in early fecundity. However, late fecundity and/or total lifetime fecundity can be higher in the populations selected for increased lifespan. This has been interpreted by some as being at odds with the [...]

By |2017-06-20T13:23:51+01:00June 20th, 2017|Papers|Comments Off on Growing more positive with age: The relationship between reproduction and survival in aging flies
Go to Top