Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair-deficient mice

Aging Cell - February 2021 Dietary restriction (DR) and rapamycin extend healthspan and life span across multiple species. We have recently shown that DR in progeroid DNA repair-deficient mice dramatically extended healthspan and trippled life span. Here, we show that rapamycin, while significantly lowering mTOR signaling, failed to improve life span nor healthspan of [...]

By |2021-04-19T14:47:37+01:00March 2nd, 2021|News, Nieuws VOILA, Papers|Comments Off on Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair-deficient mice

Emerging Role of C/EBPβ and Epigenetic DNA Methylation in Ageing

Trends in genetics - Volume 36, Issue 2, February 2020 Christof Niehrs (Institute of Molecular Biology), Cornelis F. Calkhoven (European Research Institute for the Biology of Ageing) Ageing is closely associated with and influenced by energy metabolism, and C/EBPβ is emerging as a key regulator of energy metabolism and longevity. DNA hypermethylation in GADD45α/ING1 [...]

By |2020-01-15T09:25:06+01:00January 15th, 2020|News, Papers|Comments Off on Emerging Role of C/EBPβ and Epigenetic DNA Methylation in Ageing

A meta-analysis of genome-wide association studies identifies multiple longevity genes

Nature Communications - Augustus 2019 Human longevity is heritable, but genome-wide association (GWA) studies have had limited success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity phenotype definition including 11,262/3484 cases surviving at or beyond the age corresponding to the 90th/99th survival percentile, respectively, and 25,483 controls whose age at [...]

By |2020-01-15T09:29:26+01:00September 10th, 2019|News, Papers|Comments Off on A meta-analysis of genome-wide association studies identifies multiple longevity genes

DNA methylation as a mediator of the association between prenatal adversity and risk factors for metabolic disease in adulthood

Science Advances | 03-01-2018 Abstract Although it is assumed that epigenetic mechanisms, such as changes in DNA methylation (DNAm), underlie the relationship between adverse intrauterine conditions and adult metabolic health, evidence from human studies remains scarce. Therefore, we evaluated whether DNAm in whole blood mediated the association between prenatal famine exposure and metabolic health [...]

By |2018-02-05T11:12:37+01:00February 5th, 2018|News, Papers|Comments Off on DNA methylation as a mediator of the association between prenatal adversity and risk factors for metabolic disease in adulthood

A p300 and SIRT1 Regulated Acetylation Switch of C/EBPa Controls Mitochondrial Function

Cell Press  | 9 januari 2018 | Summary Cellular metabolism is a tightly controlled process in which the cell adapts fluxes through metabolic  pathways in response to changes in nutrient supply. Among the transcription factors that regulate  gene expression and thereby cause changes in cellular metabolism is the basic leucine-zipper (bZIP) transcription factor CCAAT/enhancer-binding [...]

By |2018-01-22T10:09:37+01:00January 22nd, 2018|News, Papers|Comments Off on A p300 and SIRT1 Regulated Acetylation Switch of C/EBPa Controls Mitochondrial Function

Prolonged high-fat diet induces gradual and fat depot-specific DNA methylation changes in adult mice

Scientific reports | 03-03-2017 | Abstract High-fat diets (HFD) are thought to contribute to the development of metabolism-related diseases. The long-term impact of HFD may be mediated by epigenetic mechanisms, and indeed, HFD has been reported to induce DNA methylation changes in white adipose tissue (WAT) near metabolism related genes. However, previous studies [...]

By |2017-06-26T11:01:40+01:00June 26th, 2017|Papers|Comments Off on Prolonged high-fat diet induces gradual and fat depot-specific DNA methylation changes in adult mice

Growing more positive with age: The relationship between reproduction and survival in aging flies

Experimental Gerontology | April 2017 | Abstract Populations of laboratory animals that are selected for increased lifespan often show negative correlated responses in early fecundity. However, late fecundity and/or total lifetime fecundity can be higher in the populations selected for increased lifespan. This has been interpreted by some as being at odds with the [...]

By |2017-06-20T13:23:51+01:00June 20th, 2017|Papers|Comments Off on Growing more positive with age: The relationship between reproduction and survival in aging flies

Dietary acid load, trabecular bone integrity, and mineral density in an ageing population: the Rotterdam study

Osteoporosis International: with other metabolic bone diseases | 12-04-2017 | Abstract We studied the relation between a diet that is high in acid-forming nutrients (e.g. proteins) and low in base-forming nutrients (e.g. potassium) and bone structure. We showed a negative relation, which was more prominent if proteins were of animal rather than of [...]

By |2017-06-20T12:44:20+01:00June 20th, 2017|Papers|Comments Off on Dietary acid load, trabecular bone integrity, and mineral density in an ageing population: the Rotterdam study

Protein-enriched familiar foods and drinks improve protein intake of hospitalized older patients: A randomized controlled trial

Cilincal Nutrition  | 12-05-2017 | Abstract Background & aims: Adequate protein intake is important in preventing and treating undernutrition. Hospitalized older patients are recommended to consume 1.2e1.5 g of protein per kg body weight per day (g/kg/d) but most of them fail to do so. Therefore, we investigated whether a range of newly [...]

By |2017-06-20T09:05:58+01:00June 20th, 2017|Papers|Comments Off on Protein-enriched familiar foods and drinks improve protein intake of hospitalized older patients: A randomized controlled trial
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