The AccelerAge framework: A new statistical approach to predict biological age based on time-to-event data

By |2024-05-13T05:01:00+01:00May 13th, 2024|Papers|Comments Off on The AccelerAge framework: A new statistical approach to predict biological age based on time-to-event data

Unraveling interindividual variation of trimethylamine N‐oxide and its precursors at the population level

By |2024-05-13T04:58:17+01:00May 13th, 2024|Papers|Comments Off on Unraveling interindividual variation of trimethylamine N‐oxide and its precursors at the population level

Clarifying the biological and statistical assumptions of cross-sectional biological age predictors: an elaborate illustration using synthetic and real data

By |2024-05-13T04:58:17+01:00May 13th, 2024|Papers|Comments Off on Clarifying the biological and statistical assumptions of cross-sectional biological age predictors: an elaborate illustration using synthetic and real data

Extensive Type II Muscle Fiber Atrophy in Elderly Female Hip Fracture Patients

J Gerontol A Biol Sci Med Science | November 2016 | Abstract: Background: Sarcopenia, or the loss of muscle mass and strength, is known to increase the risk for falls and (hip) fractures in older people. The objective of this study was to assess the skeletal muscle fiber characteristics in elderly female hip [...]

By |2024-05-13T04:25:53+01:00May 13th, 2024|Papers|Comments Off on Extensive Type II Muscle Fiber Atrophy in Elderly Female Hip Fracture Patients

Later-life mortality and longevity in late-18th and 19th-century cohort: Where are we now, and where are we heading

European Historical Population Samples Network | 31-01-2017 | Abstract The limits to human lifespan are a widely discussed topic. Yet, later-life mortality and longevity are generally studied from a genetic perspective, while the social dimension has received less attention. This paper gives a systematic overview of trends in later-life mortality and longevity for [...]

By |2024-05-13T04:24:49+01:00May 13th, 2024|Papers|Comments Off on Later-life mortality and longevity in late-18th and 19th-century cohort: Where are we now, and where are we heading

Plasticity of lifelong calorie-restricted C57BL/6J mice in adapting to a medium-fat diet intervention at old age

Aging Cell | 23-09-2017| Summary Calorie restriction (CR) is a dietary regimen that supports healthy aging. In this study, we investigated the systemic and liver-specific responses caused by a diet switch to a medium-fat (MF) diet in 24-month-old lifelong, CR-exposed mice. This study aimed to increase the knowledge base on dietary alterations of [...]

By |2024-05-13T04:22:09+01:00May 13th, 2024|Papers|Comments Off on Plasticity of lifelong calorie-restricted C57BL/6J mice in adapting to a medium-fat diet intervention at old age

Reduced expression of C/EBPβ-LIP extends health and lifespan in mice

E life Sciences| 30 april 2018 Abstract Ageing is associated with physical decline and the development of age-related diseases such as metabolic disorders and cancer. Few conditions are known that attenuate the adverse effects of ageing, including calorie restriction (CR) and reduced signalling through the mechanistic target of rapamycin complex 1 (mTORC1) pathway. Synthesis [...]

By |2024-05-13T04:20:59+01:00May 13th, 2024|News, Papers|Comments Off on Reduced expression of C/EBPβ-LIP extends health and lifespan in mice
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