Doseeresponse effects of supplementation with calcifediol on serum 25-hydroxyvitamin D status and its metabolites: A randomized controlled trial in older adults

Clinical Nutrition | 26-03-2017 | Abstract Background & aims: Oral supplementation with vitamin D is recommended for older adults to maintain a sufficient 25-hydroxyvitamin D (25(OH)D) status throughout the year. While supplementation with vitamin D2 or D3 is most common, alternative treatment regimens exist which require further investigation with respect to increasing 25(OH)D [...]

By |2017-06-20T10:04:33+01:00June 20th, 2017|Papers|Comments Off on Doseeresponse effects of supplementation with calcifediol on serum 25-hydroxyvitamin D status and its metabolites: A randomized controlled trial in older adults

Activation-Induced Autophagy Is Preserved in CD4+ T-Cells in Familial Longevity

The Journal of Gerontology  | 09-05-2017 | Abstract As with many other tissues and organs, the immune system is also affected by age. Immunosenescence is characterized by a decreased ability of immune cells to mount a productive response upon exposure to new antigens. Several studies have reported that members of families with exceptional [...]

By |2017-06-20T09:09:34+01:00June 19th, 2017|Papers|Comments Off on Activation-Induced Autophagy Is Preserved in CD4+ T-Cells in Familial Longevity

Cellular senescence drives age-dependent hepatic steatosis

Nature Communications - 13-06-2017 Abstract: The incidence of non-alcoholic fatty liver disease (NAFLD) increases with age. Cellular senescence refers to a state of irreversible cell-cycle arrest combined with the secretion of proinflammatory cytokines and mitochondrial dysfunction. Senescent cells contribute to age-related tissue degeneration. Here we show that the accumulation of senescent cells promotes hepatic [...]

By |2017-06-19T08:54:33+01:00June 19th, 2017|Papers|Comments Off on Cellular senescence drives age-dependent hepatic steatosis

Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

Cell - March 2017 Abstract The accumulation of irreparable cellular damage restricts healthspan after acute stress or natural aging. Senescent cells are thought to impair tissue function and their genetic clearance can delay features of aging. Identifying how senescent cells avoid apoptosis allows for the prospective design of anti-senescence compounds to address whether homeostasis can [...]

By |2017-06-19T09:23:56+01:00March 7th, 2017|Papers|Comments Off on Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

Employing biomarkers of healthy ageing for leveraging genetic studies into human longevity

Experimental Gerontology - 29-06-2016 Abstract: Genetic studies have thus far identified a limited number of loci associated with human longevity by applying age at death or survival up to advanced ages as phenotype. As an alternative approach, one could first try to identify biomarkers of healthy ageing and the genetic variants associated with these [...]

By |2017-06-19T09:26:00+01:00March 7th, 2017|Papers|Comments Off on Employing biomarkers of healthy ageing for leveraging genetic studies into human longevity

Resistance Training Increases Skeletal Muscle Capillarization in Healthy Older Men

Medicine and science in sports and exercise -  November 2016 Abstract PURPOSE: Skeletal muscle capillarization plays a key role in oxygen and nutrient delivery to muscle. The loss of muscle mass with aging and the concept of anabolic resistance have been, at least partly, attributed to changes in skeletal muscle capillary structure and [...]

By |2017-06-19T09:27:23+01:00February 20th, 2017|Papers|Comments Off on Resistance Training Increases Skeletal Muscle Capillarization in Healthy Older Men

Expression of protocadherin gamma in skeletal muscle tissue is associated with age and muscle weakness

J Cachexia Sarcopenia Muscle -  December 2016 Abstract BACKGROUND: The skeletal muscle system plays an important role in the independence of older adults. In this study we examine differences in the skeletal muscle transcriptome between healthy young and older subjects and (pre-)frail older adults. Additionally, we examine the effect of resistance-type exercise training [...]

By |2017-06-19T09:28:41+01:00February 20th, 2017|Papers|Comments Off on Expression of protocadherin gamma in skeletal muscle tissue is associated with age and muscle weakness

Both basal and post-prandial muscle protein synthesis rates, following the ingestion of a leucine-enriched whey protein supplement, are not impaired in sarcopenic older males.

Clinical Nutrition - September 2016 Abstract BACKGROUND: Studying the muscle protein synthetic response to food intake in elderly is important, as it aids the development of interventions to combat sarcopenia. Although sarcopenic elderly are the target group for many of these nutritional interventions, no studies have assessed basal or post-prandial muscle protein synthesis rates [...]

By |2017-06-19T09:29:55+01:00February 20th, 2017|Papers|Comments Off on Both basal and post-prandial muscle protein synthesis rates, following the ingestion of a leucine-enriched whey protein supplement, are not impaired in sarcopenic older males.

Muscle fibre capillarization is a critical factor in muscle fibre hypertrophy during resistance exercise training in older men

Journal of Cachexia, Sarcopenia and Muscle | 04-08-2016| Abstract: Background: Adequate muscle fiber perfusion is critical for the maintenance of muscle mass, it is essential in the rapid delivery of oxygen, nutrients and growth factors to the muscle, stimulating muscle fiber growth. Muscle fiber capillarization is known to decrease substantially with advancing age. However, [...]

By |2017-01-30T14:44:36+01:00January 30th, 2017|Papers|Comments Off on Muscle fibre capillarization is a critical factor in muscle fibre hypertrophy during resistance exercise training in older men

Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms 

Genome Biology | September 2016 | Background Epigenetic change is a hallmark of ageing but its link to ageing mechanisms in humans remains poorly understood. While DNA methylation at many CpG sites closely tracks chronological age, DNA methylation changes relevant to biological age are expected to gradually dissociate from chronological age, mirroring the increased heterogeneity [...]

By |2016-12-20T09:17:27+01:00December 20th, 2016|Papers|Comments Off on Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms