Both basal and post-prandial muscle protein synthesis rates, following the ingestion of a leucine-enriched whey protein supplement, are not impaired in sarcopenic older males.

Clinical Nutrition - September 2016 Abstract BACKGROUND: Studying the muscle protein synthetic response to food intake in elderly is important, as it aids the development of interventions to combat sarcopenia. Although sarcopenic elderly are the target group for many of these nutritional interventions, no studies have assessed basal or post-prandial muscle protein synthesis rates [...]

By |2017-06-19T09:29:55+01:00February 20th, 2017|Papers|Comments Off on Both basal and post-prandial muscle protein synthesis rates, following the ingestion of a leucine-enriched whey protein supplement, are not impaired in sarcopenic older males.

Muscle fibre capillarization is a critical factor in muscle fibre hypertrophy during resistance exercise training in older men

Journal of Cachexia, Sarcopenia and Muscle | 04-08-2016| Abstract: Background: Adequate muscle fiber perfusion is critical for the maintenance of muscle mass, it is essential in the rapid delivery of oxygen, nutrients and growth factors to the muscle, stimulating muscle fiber growth. Muscle fiber capillarization is known to decrease substantially with advancing age. However, [...]

By |2017-01-30T14:44:36+01:00January 30th, 2017|Papers|Comments Off on Muscle fibre capillarization is a critical factor in muscle fibre hypertrophy during resistance exercise training in older men

Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms 

Genome Biology | September 2016 | Background Epigenetic change is a hallmark of ageing but its link to ageing mechanisms in humans remains poorly understood. While DNA methylation at many CpG sites closely tracks chronological age, DNA methylation changes relevant to biological age are expected to gradually dissociate from chronological age, mirroring the increased heterogeneity [...]

By |2016-12-20T09:17:27+01:00December 20th, 2016|Papers|Comments Off on Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms 

Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice

Nature | August 2016| Summary Mice deficient in the DNA excision-repair gene Ercc1 (Ercc1∆/−) show numerous accelerated ageing features that limit their lifespan to 4-6 months1, 2, 3, 4. They also exhibit a ‘survival response’, which suppresses growth and enhances cellular maintenance. Such a response resembles the anti-ageing response induced by dietary restriction [...]

By |2017-06-20T10:08:02+01:00August 25th, 2016|Papers|Comments Off on Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice

Ectopic miR-125a Expression Induces Long-Term Repopulating Stem Cell Capacity in Mouse and Human Hematopoietic Progenitors

Edyta E. Wojtowicz9, Eric R. Lechman9, Karin G. Hermans9, Erwin M. Schoof, Erno Wienholds, Ruth Isserlin, Peter A. van Veelen, Mathilde J.C. Broekhuis,George M.C. Janssen, Aaron Trotman-Grant, Stephanie M. Dobson, Gabriela Krivdova, Jantje Elzinga, James Kennedy, Olga I. Gan, Ankit Sinha, Vladimir Ignatchenko, Thomas Kislinger, Bertien Dethmers-Ausema, Ellen Weersing, Mir Farshid Alemdehy, Hans W.J. de Looper, Gary D. Bader, Martha Ritsema, Stefan J. Erkeland, Leonid V. Bystrykh10, John E. Dick10, Gerald de Haan10  9Co-first author, 10Co-senior author Umbilical cord blood (CB) is a convenient and broadly used source of hematopoietic stem cells (HSCs) for allogeneic stem cell transplantation. However, [...]

By |2017-03-06T10:59:09+01:00August 8th, 2016|Papers|Comments Off on Ectopic miR-125a Expression Induces Long-Term Repopulating Stem Cell Capacity in Mouse and Human Hematopoietic Progenitors
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