Thanh Hoang et al. published a paper “Comprehensive evaluation of smoking exposures and their interactions on DNA methylation” in eBioMedicine in February 2024
Many smoking-related methylation sites were identified with Illumina’s EPIC array. Most signals revert to levels observed in never smokers within a year of cessation. Many in utero smoking CpGs persist into adulthood. Smoking-related druggable targets may provide insights into cancer treatment response and shared mechanisms across smoking-related diseases. Data of the Dutch BBMRI BIOS Consortium contributed to this research
