Pol Grootswagers published a paper “Discovering the direct relations between nutrients and epigenetic ageing” in The Journal of Nutrition, Health and Aging in September 2024. “In our recent study, we explored the direct relationships between nutrient intake and epigenetic ageing using data from 3,969 postmenopausal women participating in the Women’s Health Initiative. We utilized the PhenoAge epigenetic clock to measure biological age, and used the data-driven network analysis Copula Graphical Modelling to objectively identify associations in the dataset while extensively controlling for every confounder that was measured. Our analysis revealed that higher dietary intakes of coumestrol, beta-carotene, and arachidic acid are associated with decelerated epigenetic ageing. Coumestrol, a phytoestrogen found in soy products and wheat germ, showed significant potential in slowing down ageing, perhaps due to its antioxidant properties. Similarly, beta-carotene, an antioxidant prevalent in fruits and vegetables, also demonstrated a deceleration effect on biological ageing. Conversely, increased consumption of added sugar, gondoic acid, behenic acid, arachidonic acid, vitamin A, and ash (which mainly reflects sodium) were linked to accelerated epigenetic ageing. Added sugar was strongly associated with faster ageing, likely due to its role in oxidative stress and inflammation. The intake of certain fatty acids and vitamin A, predominantly sourced from animal-based foods, also correlated with an increased ageing rate. Our findings underscore the significant impact of specific nutrients on the ageing process, suggesting potential dietary interventions to promote healthier ageing. Further research is needed to confirm these associations and explore the underlying mechanisms in different populations and through varied research designs. If you are interested in applying Copula Graphical Modelling in your dataset as well, please contact pol.grootswagers@wur.nl. The method is highly suitable for identification of determinants underlying ageing, or other health outcomes of interest. ” Link to full article: https://doi.org/10.1016/j.jnha.2024.100324
