Enzymatic and non-enzymatic oxidation of polyunsaturated fatty acids leads to the formation of biologically active metabolites, known as lipid mediators. These can be exported extracellularly, and then sequestrated rapidly to stimulate cellular autocrine or paracrine pathways. Lipid mediators are involved in many physiological processes and their dysregulations have been observed in ageing and often linked to various lipid-based diseases such as diabetes, atherosclerosis, arthritis, cancer, Alzheimer’s disease and metabolic syndrome.
This focus group meeting aims to bring together knowledge of lipid mediators across ageing and inflammatory diseases to underpin their importance to life sciences and clinical applications.
Philip C. Calder (University of Southampton, UK and President of the Nutrition Society)
Anna Nicolaou (The University of Manchester, UK)
Charles Serhan (Brigham and Women’s Hospital/Harvard Medical School, U.S.A.)
Mauro Perretti (Barts and The London School of Medicine, UK)
Petroula Proitsi (King’s College London, UK)
Valerie O’Donnell (Cardiff University, United Kingdom)