Papers

Pol Grootswagers published a paper "Meal Protein Quality Score: A novel tool to evaluate protein quantity and quality of meals" in Current Developments in Nutrition in August 2024. Background The recent shift towards increased plant-based protein consumption has necessitated the development of new tools to evaluate the quality and quantity of protein in meals, especially given the changing dietary guidelines and the adoption of plant-centric menus in healthcare and other settings. Objective To develop [...]

Pol Grootswagers published a paper “Discovering the direct relations between nutrients and epigenetic ageing” in The Journal of Nutrition, Health and Aging in September 2024. “In our recent study, we explored the direct relationships between nutrient intake and epigenetic ageing using data from 3,969 postmenopausal women participating in the Women’s Health Initiative. We utilized the PhenoAge epigenetic clock to measure biological age, and used the data-driven network analysis Copula Graphical Modelling to objectively identify [...]

Fatih Bogaards published a paper "Secondary integrated analysis of multi-tissue transcriptomic responses to a combined lifestyle intervention in older adults from the GOTO nonrandomized trial" in Nature Communication in August 2024. Molecular effects of lifestyle interventions are typically studied in a single tissue. Here, we perform a secondary analysis on the sex-specific effects of the Growing Old TOgether trial (GOTO, trial registration number GOT NL3301 (https://onderzoekmetmensen.nl/nl/trial/27183), NL-OMON27183, primary outcomes have been previously reported in [...]

Jordi Morwani-Mangnarni published a paper “Physical activity and fiber intake beneficial for muscle mass and strength preservation during aging: A Comprehensive Cross-Sectional Study in the UK Biobank cohort” in Experimental Gerontology in August 2024. “Aging triggers intricate physiological changes, particularly in whole-body fat-free mass (FFM) and handgrip strength, affecting overall health and independence. Despite existing research, the broader significance of how muscle health is affected by the intricate [...]

Yara van Holstein published a paper “The performance of metabolomics-based prediction scores for mortality in older patients with solid tumors” in GeroScience in July 2024 Prognostic information is needed to balance benefits and risks of cancer treatment in older patients. Metabolomics-based scores were previously developed to predict 5- and 10-year mortality (MetaboHealth) and biological age (MetaboAge). This study aims to investigate the association of MetaboHealth and MetaboAge with 1-year mortality in older patients with [...]

Kerstin Schorr published a narrative review "A plant-based diet index to study the relation between diet and disease risk among adults: a narrative review" in the Journal of Nutrition, Health and Aging in June 2024 Plant-based diets (PBD) may offer various health benefits and contribute to a sustainable way of life, but, if not planned correctly, may also confer risks, e.g., by focusing on plant foods with low nutrient density, such as foods primarily [...]

Ynte Biemans published a paper "Identifying the relation between food groups and biological ageing: a data-driven approach" in Age and Ageing in May 2024 Heterogeneity in ageing rates highlights the need for research into lifestyle factors that contribute to successful ageing. Biological age, estimated by epigenetic clocks, is a more accurate measure of ageing compared to chronological age. While dietary habits are known to affect the ageing process, associations have been weak and inconsistent [...]

Marije Sluiskes et al. published a paper "The AccelerAge framework: A new statistical approach to predict biological age based on time-to-event data" in European Journal of Epidemiology in April 2024 They compare predictors based on the AccelerAge framework to a predictor based on the GrimAge predictor, which is considered one of the best-performing biological age predictors, using simulated data as well as data from the UK Biobank (https://www.ukbiobank.ac.uk/) and the Leiden Longevity Study (https://leidenlangleven.nl/). [...]

Annelien de Kat et al. published a paper “Late reproduction is associated with extended female survival but not with familial longevity” in Reproductive BioMedicine Online in April 2024! “They concluded that female reproductive health associates with a longer lifespan, though women from long-lived families do not show extended reproductive health. Other factors in somatic maintenance that support a longer lifespan are likely to have an impact on reproductive health. They studied 10,255 females from [...]

Sergio Andreu-Sánchez et al. published a paper "Unraveling interindividual variation of trimethylamine N‐oxide and its precursors at the population level" in iMeta in March 2024 Trimethylamine N-oxide (TMAO) is a circulating microbiome-derived metabolite implicated in the development of atherosclerosis and cardiovascular disease (CVD). They investigated whether plasma levels of TMAO, its precursors (betaine, carnitine, deoxycarnitine, choline), and TMAO-to-precursor ratios are associated with clinical outcomes, including CVD and mortality. This was followed by an in-depth [...]