Papers
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Aging Cell - February 2021 Dietary restriction (DR) and rapamycin extend healthspan and life span across multiple species. We have recently shown that DR in progeroid DNA repair-deficient mice dramatically extended healthspan and trippled [...]
Trends in genetics - Volume 36, Issue 2, February 2020 Christof Niehrs (Institute of Molecular Biology), Cornelis F. Calkhoven (European Research Institute for the Biology of Ageing) Ageing is closely associated with and influenced [...]
Nature Communications - Augustus 2019 Human longevity is heritable, but genome-wide association (GWA) studies have had limited success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity phenotype definition including 11,262/3484 [...]
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Science Advances | 03-01-2018 Abstract Although it is assumed that epigenetic mechanisms, such as changes in DNA methylation (DNAm), underlie the relationship between adverse intrauterine conditions and adult metabolic health, evidence from human studies [...]
Cell Press | 9 januari 2018 | Summary Cellular metabolism is a tightly controlled process in which the cell adapts fluxes through metabolic pathways in response to changes in nutrient supply. Among the transcription [...]
Scientific reports | 03-03-2017 | Abstract High-fat diets (HFD) are thought to contribute to the development of metabolism-related diseases. The long-term impact of HFD may be mediated by epigenetic mechanisms, and indeed, HFD [...]
Experimental Gerontology | April 2017 | Abstract Populations of laboratory animals that are selected for increased lifespan often show negative correlated responses in early fecundity. However, late fecundity and/or total lifetime fecundity can be [...]
Osteoporosis International: with other metabolic bone diseases | 12-04-2017 | Abstract We studied the relation between a diet that is high in acid-forming nutrients (e.g. proteins) and low in base-forming nutrients (e.g. potassium) [...]
Cilincal Nutrition | 12-05-2017 | Abstract Background & aims: Adequate protein intake is important in preventing and treating undernutrition. Hospitalized older patients are recommended to consume 1.2e1.5 g of protein per kg body [...]
