Papers
Do you have a paper that you would like to bring to the attention of our members, please send an email via the contact page.
The Netherlands Consortium of Dementia Cohorts has performed a meta-analysis with 8 cohort studies to investigate the associations between depressive symptoms later in life and plasma markers for Alzheimer’s disease and neurodegeneration. The Leiden [...]
A shift towards a more plant-based diet is promoted as healthy as well as sustainable. Whether this also applies to older adults is however less clear: On one hand plant-based diets may lead to [...]
Aging Cell - February 2021 Dietary restriction (DR) and rapamycin extend healthspan and life span across multiple species. We have recently shown that DR in progeroid DNA repair-deficient mice dramatically extended healthspan and trippled [...]
Trends in genetics - Volume 36, Issue 2, February 2020 Christof Niehrs (Institute of Molecular Biology), Cornelis F. Calkhoven (European Research Institute for the Biology of Ageing) Ageing is closely associated with and influenced [...]
Nature Communications - Augustus 2019 Human longevity is heritable, but genome-wide association (GWA) studies have had limited success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity phenotype definition including 11,262/3484 [...]
Read the article
Science Advances | 03-01-2018 Abstract Although it is assumed that epigenetic mechanisms, such as changes in DNA methylation (DNAm), underlie the relationship between adverse intrauterine conditions and adult metabolic health, evidence from human studies [...]
Cell Press | 9 januari 2018 | Summary Cellular metabolism is a tightly controlled process in which the cell adapts fluxes through metabolic pathways in response to changes in nutrient supply. Among the transcription [...]
Scientific reports | 03-03-2017 | Abstract High-fat diets (HFD) are thought to contribute to the development of metabolism-related diseases. The long-term impact of HFD may be mediated by epigenetic mechanisms, and indeed, HFD [...]
Experimental Gerontology | April 2017 | Abstract Populations of laboratory animals that are selected for increased lifespan often show negative correlated responses in early fecundity. However, late fecundity and/or total lifetime fecundity can be [...]