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Papers2024-05-10T05:30:21+01:00

Papers

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Clarifying the biological and statistical assumptions of cross-sectional biological age predictors: an elaborate illustration using synthetic and real data

Marije Sluiskes et al. published a paper "Clarifying the biological and statistical assumptions of cross-sectional biological age predictors: an elaborate illustration using synthetic and real data" in BMC Medical Research Methodology in March 2024 Their main conclusion was that cross-sectional methods for predicting biological age commonly use the untestable identical-association assumption, which previous literature in the field had never explicitly acknowledged. These methods have inherent limitations and may provide uninformative results, highlighting the importance [...]

Categorieën: Papers|

A conserved complex lipid signature marks human muscle aging and responds to short-term exercise

Georges Janssens et al. published a paper “A conserved complex lipid signature marks human muscle aging and responds to short-term exercise” in Nature Aging in February 2024 Studies in preclinical models suggest that complex lipids, such as phospholipids, play a role in the regulation of longevity. However, identification of universally conserved complex lipid changes that occur during aging, and how these respond to interventions, is lacking. Here, to comprehensively map how complex lipids change [...]

Categorieën: Papers|

Comprehensive evaluation of smoking exposures and their interactions on DNA methylation

Thanh Hoang et al. published a paper "Comprehensive evaluation of smoking exposures and their interactions on DNA methylation" in eBioMedicine in February 2024 Many smoking-related methylation sites were identified with Illumina’s EPIC array. Most signals revert to levels observed in never smokers within a year of cessation. Many in utero smoking CpGs persist into adulthood. Smoking-related druggable targets may provide insights into cancer treatment response and shared mechanisms across smoking-related diseases. Data of the [...]

Categorieën: Papers|

The association of blood biomarkers with treatment response and adverse health outcomes in older patients with solid tumors: A systematic review

Yara van Holsteing et al. published a systematic review "The association of blood biomarkers with treatment response and adverse health outcomes in older patients with solid tumors: A systematic review" in the Journal of Geriatric Oncology in September 2023 Blood biomarkers are potentially useful prognostic markers and may support treatment decisions, but it is unknown if and which biomarkers are most useful in older patients with solid tumors. The aim of this systematic review [...]

Categorieën: Papers|

Increasing number of long-lived ancestors marks a decade of healthspan extension and healthier metabolomics profiles

Niels van den Berg published a paper "Increasing number of long-lived ancestors marks a decade of healthspan extension and healthier metabolomics profiles" in Nature Communications in July 2023Globally, the lifespan of populations increases but the healthspan is lagging behind. Previous research showed that survival into extreme ages (longevity) clusters in families as illustrated by the increasing lifespan of study participants with each additional long-lived family member. Here they investigate whether the healthspan in such families [...]

Categorieën: Papers|

Associatie gevonden tussen depressieve symptomen en plasma markers voor de ziekte van Alzheimer

Het Nederlands Consortium of Dementie Cohorten heeft een meta-analyse gedaan met 8 cohort studies om te onderzoeken of plasma markers voor Alzheimer en neurodegeneratie associëren met depressieve symptomen later in het leven. De Leiden LangLeven Studie was één van de 8 deelnemende cohorten. De bevindingen zijn nu gepubliceerd in “The American Journal of Geriatric Psychiatry”. Deze studie heeft onderzocht of depressieve symptomen later in het leven geassocieerd zijn met plasma amyloid-beta42/40, p-tau181, neurofilament light, [...]

Categorieën: Nieuws, Papers, Uitgelichte mededelingen|

Healthful plant-based diet associates with greater well-being in older adults

A shift towards a more plant-based diet is promoted as healthy as well as sustainable. Whether this also applies to older adults is however less clear: On one hand plant-based diets may lead to energy deficits among vulnerable older adults and therefore negatively impact well-being. On the other hand, plant-based diets have been found to have anti-inflammatory properties, suggesting they could be beneficial to older adults, often prone to chronic inflammation. We just published [...]

Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair-deficient mice

Aging Cell - February 2021 Dietary restriction (DR) and rapamycin extend healthspan and life span across multiple species. We have recently shown that DR in progeroid DNA repair-deficient mice dramatically extended healthspan and trippled life span. Here, we show that rapamycin, while significantly lowering mTOR signaling, failed to improve life span nor healthspan of DNA repair-deficient Ercc1∆/- mice, contrary to DR tested in parallel. Rapamycin interventions focusing on dosage, gender, and timing all were [...]

Categorieën: Nieuws, Nieuws VOILA, Papers|

Emerging Role of C/EBPβ and Epigenetic DNA Methylation in Ageing

Trends in genetics - Volume 36, Issue 2, February 2020 Christof Niehrs (Institute of Molecular Biology), Cornelis F. Calkhoven (European Research Institute for the Biology of Ageing) Ageing is closely associated with and influenced by energy metabolism, and C/EBPβ is emerging as a key regulator of energy metabolism and longevity. DNA hypermethylation in GADD45α/ING1 mutant mice is associated with progeria due to a failure of TET-dioxygenase mediated demethylation of C/EBPβ binding sites. Accordingly, GADD45α/ING1 mutant [...]

Categorieën: Nieuws, Papers|

A meta-analysis of genome-wide association studies identifies multiple longevity genes

Nature Communications - Augustus 2019 Human longevity is heritable, but genome-wide association (GWA) studies have had limited success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity phenotype definition including 11,262/3484 cases surviving at or beyond the age corresponding to the 90th/99th survival percentile, respectively, and 25,483 controls whose age at death or at last contact was at or below the age corresponding to the 60th survival percentile. Consistent with previous [...]

Categorieën: Nieuws, Papers|
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