Papers
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Langlevendheid is vooral erfelijk in extreem langlevende families
Persbericht LUMC - 7 januari 2019 Een lang leven is erfelijk, maar dat geldt primair voor personen uit families waarvan meerdere leden behoren tot de top tien procent overlevers van hun generatie. In de genen van deze families ligt waarschijnlijk de sleutel tot een lang leven. Dat schrijven onderzoekers van het Leids Universitair Medisch Centrum samen met Amerikaanse en Nijmeegse collega’s in Nature Communications. De onderzoekers kwamen tot hun conclusies na het bestuderen van [...]
Eline Slagboom en collega’s publiceren Review in Nature over verouderingsonderzoek
Facing up to the global challenges of ageing Linda Partridge, Joris Deelen & P. Eline Slagboom Longer human lives have led to a global burden of late-life disease. However, some older people experience little ill health, a trait that should be extended to the general population. Interventions into lifestyle, including increased exercise and reduction in food intake and obesity, can help to maintain healthspan. Altered gut microbiota, removal of senescent cells, blood factors obtained from young individuals [...]
Worms may hold the secret to longer life
Horizon - The EU Research & Innovation Magazine 5 juli 2018 The regenerative abilities of the flatworm Macrostomum lignano serve as a model for how humans might regenerate tissues. Image credit - Flickr/ Lukas Schärer, licensed under CC BY-SA 2.0 Research into the remarkable regenerative powers of worms and the insights they can give into battling diseases could help humans live longer and healthier lives. Humans have long dreamed of finding the secret to [...]
Reduced expression of C/EBPβ-LIP extends health and lifespan in mice
E life Sciences| 30 april 2018 Abstract Ageing is associated with physical decline and the development of age-related diseases such as metabolic disorders and cancer. Few conditions are known that attenuate the adverse effects of ageing, including calorie restriction (CR) and reduced signalling through the mechanistic target of rapamycin complex 1 (mTORC1) pathway. Synthesis of the metabolic transcription factor C/EBPβ-LIP is stimulated by mTORC1, which critically depends on a short upstream open reading frame [...]
DNA methylation as a mediator of the association between prenatal adversity and risk factors for metabolic disease in adulthood
Science Advances | 03-01-2018 Abstract Although it is assumed that epigenetic mechanisms, such as changes in DNA methylation (DNAm), underlie the relationship between adverse intrauterine conditions and adult metabolic health, evidence from human studies remains scarce. Therefore, we evaluated whether DNAm in whole blood mediated the association between prenatal famine exposure and metabolic health in 422 individuals exposed to famine in utero and 463 (sibling) controls. We implemented a two-step analysis, namely, a genome-wide [...]
A p300 and SIRT1 Regulated Acetylation Switch of C/EBPa Controls Mitochondrial Function
Cell Press | 9 januari 2018 | Summary Cellular metabolism is a tightly controlled process in which the cell adapts fluxes through metabolic pathways in response to changes in nutrient supply. Among the transcription factors that regulate gene expression and thereby cause changes in cellular metabolism is the basic leucine-zipper (bZIP) transcription factor CCAAT/enhancer-binding protein alpha (C/EBPa). Protein lysine acetylation is a key post-translational modification (PTM) that integrates cellular metabolic cues with other physiological [...]
Plasticity of lifelong calorie-restricted C57BL/6J mice in adapting to a medium-fat diet intervention at old age
Aging Cell | 23-09-2017| Summary Calorie restriction (CR) is a dietary regimen that supports healthy aging. In this study, we investigated the systemic and liver-specific responses caused by a diet switch to a medium-fat (MF) diet in 24-month-old lifelong, CR-exposed mice. This study aimed to increase the knowledge base on dietary alterations of gerontological relevance. Nine-week-old C57BL/6J mice were exposed either to a control, CR, or MF diet. At the age of 24 [...]
Prolonged high-fat diet induces gradual and fat depot-specific DNA methylation changes in adult mice
Scientific reports | 03-03-2017 | Abstract High-fat diets (HFD) are thought to contribute to the development of metabolism-related diseases. The long-term impact of HFD may be mediated by epigenetic mechanisms, and indeed, HFD has been reported to induce DNA methylation changes in white adipose tissue (WAT) near metabolism related genes. However, previous studies were limited to a single WAT depot, a single time-point and primarily examined the pre-pubertal period. To define dynamic DNA [...]
Growing more positive with age: The relationship between reproduction and survival in aging flies
Experimental Gerontology | April 2017 | Abstract Populations of laboratory animals that are selected for increased lifespan often show negative correlated responses in early fecundity. However, late fecundity and/or total lifetime fecundity can be higher in the populations selected for increased lifespan. This has been interpreted by some as being at odds with the disposable soma theory, which predicts decreased lifespan to increase total reproductive output. Alternatively, the Y–model explores the effects of variation [...]
Dietary acid load, trabecular bone integrity, and mineral density in an ageing population: the Rotterdam study
Osteoporosis International: with other metabolic bone diseases | 12-04-2017 | Abstract We studied the relation between a diet that is high in acid-forming nutrients (e.g. proteins) and low in base-forming nutrients (e.g. potassium) and bone structure. We showed a negative relation, which was more prominent if proteins were of animal rather than of vegetable origin and if intake of dietary fibre was high. Introduction: Studies on dietary acid load (DAL) and fractures have [...]
