NEWS
Leiden-Brazil Summer School on Data Science in Health and Disease – June 7 -17th 2021
This online summer course will stimulate international collaborations between students from Brazil and Leiden. The course will provide an introduction to the use of big data analysis in health and disease. The programme, including theory and practical modules, will focus on diverse hospital data, “omics data” and application thereof in prediction, prognosis and understanding of disease. Students will have the opportunity to interact with each other in culturally diverse groups. Brazil - Leiden cooperation on [...]
Signatures DuSRA – researchers on the website
In recent years, the DuSRA has developed into a serious discussion partner. Discussions have taken place with subsidy providers, such as ZonMW and Health-Holland. Meetings have been organized to learn about each other's expertise and collaborations have been started. A good example of this is VOILA. Now is the time to think about the future. We hear from our partners a need for cooperation, for example in the process of writing grants. In order [...]
Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair-deficient mice
Aging Cell - February 2021 Dietary restriction (DR) and rapamycin extend healthspan and life span across multiple species. We have recently shown that DR in progeroid DNA repair-deficient mice dramatically extended healthspan and trippled life span. Here, we show that rapamycin, while significantly lowering mTOR signaling, failed to improve life span nor healthspan of DNA repair-deficient Ercc1∆/- mice, contrary to DR tested in parallel. Rapamycin interventions focusing on dosage, gender, and timing all were [...]
Welcome Trust Meeting on Longitudinal studies – March 9-12-2021
Due to the evolving situation with Covid-19, this meeting was postponed from 20-22 April 2020 and will now be held as a virtual conference. Longitudinal studies are ideal tools for studying many things including age-related functional changes, and the development and progression of chronic diseases. This conference will bring together scientists working on studies in childhood, adult and late life to identify novel biomarkers of functional decline and development of disease susceptibility, and to [...]
NWO Life2021 – call for abstracts staat open
Wat is NWO Life? Life is een uniek jaarlijks wetenschappelijk congres dat NWO organiseert voor alle levenswetenschappers binnen Nederland. In de volle breedte en op alle schaalniveaus: van femtometer tot kilometer, van cel tot planeet. NWO Life is bedoeld om senior en junior onderzoekers uit alle disciplines van het brede spectrum dat de Nederlandse levenswetenschappen omvat, te verbinden, te inspireren, grenzen te verkennen en te discussiëren over nieuwe en gewenste ontwikkelingen in het veld. [...]
Emerging Role of C/EBPβ and Epigenetic DNA Methylation in Ageing
Trends in genetics - Volume 36, Issue 2, February 2020 Christof Niehrs (Institute of Molecular Biology), Cornelis F. Calkhoven (European Research Institute for the Biology of Ageing) Ageing is closely associated with and influenced by energy metabolism, and C/EBPβ is emerging as a key regulator of energy metabolism and longevity. DNA hypermethylation in GADD45α/ING1 mutant mice is associated with progeria due to a failure of TET-dioxygenase mediated demethylation of C/EBPβ binding sites. Accordingly, GADD45α/ING1 mutant [...]
Vacature University of Michigan
Tenured and Tenure-Track Biogerontology Faculty Positions: University of Michigan The University of Michigan Geriatrics Center is seeking to hire one or more tenure track faculty members to carry out research focused on the biology of aging and the relationship of aging processes to late life diseases. We are interested in considering both new investigators, and also creative and successful mid-career or senior scientists whose research programs focus on questions related to aging. The ideal [...]
Happy New Year!
The DuSRA-board wishes all her members and their family a Healthy and Happy New Year!
3 Molecular Biology of Ageing Meeting – October 10 – 12, 2019 Groningen, The Netherlands
We are pleased to announce the 3rd Meeting on the Molecular Biology of Ageing that will take place from Thursday afternoon till Saturday Evening, October 10-12, 2019, in Groningen, The Netherlands. We cordially invite you to attend the meeting on the Molecular Biology of Ageing and submit an abstract for oral or poster presentation. This meeting brings together world-leading scientists to discuss the diverse research areas that are relevant for understanding the biology of ageing. [...]
A meta-analysis of genome-wide association studies identifies multiple longevity genes
Nature Communications - Augustus 2019 Human longevity is heritable, but genome-wide association (GWA) studies have had limited success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity phenotype definition including 11,262/3484 cases surviving at or beyond the age corresponding to the 90th/99th survival percentile, respectively, and 25,483 controls whose age at death or at last contact was at or below the age corresponding to the 60th survival percentile. Consistent with previous [...]
